2 edition of Drug-induced attenuation of voluntary ethanol consumption in laboratory animals. found in the catalog.
Drug-induced attenuation of voluntary ethanol consumption in laboratory animals.
Linda Anne Forgie
Written in English
|The Physical Object|
|Number of Pages||121|
RESULTS: The intermittent-access 20% ethanol 2-bottle-choice drinking paradigm led standard laboratory rats to escalate their ethanol intake over the first 5 to 6 drinking sessions, reaching stable baseline consumption of high amounts of ethanol (Long-Evans: +/- ; Wistar: +/- g/kg/24 h, respectively).Cited by: Polydrug use is a pattern that has been observed in many drug-using populations (EMCDDA ), among them heroin addicts (Darke and Hall ). Ethanol is one of the drugs most commonly found in addition to heroin (Rook et al. ) and studies have suggested that the intake of ethanol is a risk factor in heroin related deathsAuthor: Karianne Slåtta Haugen.
title = "Voluntary ethanol consumption in 22 inbred mouse strains", abstract = "Inbred strains are genetically stable across time and laboratories, allowing scientists to accumulate a record of phenotypes, including physiological characteristics and by: Abstract. Aims: Effects of l-arginine, a nitric oxide (NO) precursor, on ethanol withdrawal syndrome were investigated in s: Ethanol (% v/v) was given to rats by a liquid diet for 16 days. l-Arginine (, and mg/kg) or saline were injected into rats intraperitoneally 20 min before ethanol withdrawal. All injections were repeated 30 min before Cited by:
Catalyzed in part by this article, the Laboratory Animal Welfare Act, the first version of what is now known as the Animal Welfare Act (AWA), was passed by Congress in (Public Law ) establishing legal standards for laboratory animal care and use for the first time in . Comparison of voluntary ethanol intake by two pairs of rat lines used as genetic models of anxiety in which two bottles of either ethanol solution or water were made available continuously as a free choice to the animals. The h consumption of ethanol or water was measured daily at am. the present results provide evidence for.
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Nevertheless, in the same study it has been shown that voluntary EtOH consumption abolished the hypersensitivity of SI animals to acute novel stress, as demonstrated by the attenuation of the increase in the cerebrocortical concentration of 3α,5α-TH PROG induced by foot shock stress (Pisu et al., ).Cited by: Drug-induced changes in the voluntary intake of ethanol by experimental animals are known to be influenced by the appetite for calories and for water.
Thus, at least a part of these changes can be considered nonspecific for : J. Mardones, R. Alvarado, S. Contreras, N. Segovia-Riquelme. We used SI in C57BL/6J mice to investigate the effects of ethanol (EtOH) in the free-choice drinking paradigm on gene expression and function of γ-aminobutyric acid type A receptors (GABA(A)Rs) and the role of neuroactive steroids in the actions of EtOH in the hippocampus.
Interestingly, the changes in voluntary ethanol consumption in LHb-lesioned animals were accompanied by an attenuation of ethanol-induced CTA. Consistent with these findings, a more recent report has shown that pharmacological inactivation of the LHb eliminates ethanol-induced place aversion (Zuo et al.
).Cited by: 6. Previous research demonstrated that serotonin uptake blockers (e. g., zimeldine, sertraline, fluoxetine) reduce voluntary ethanol consumption in rats and humans.
However, the mechanism of action of these compounds is not well by: Voluntary ethanol consumption and preference occurred under the two-bottle, free-choice paradigm, as previously described [29,36,40, 41, . In brief. The present study examined the effect of different doses of a newly developed nontoxic ibogaine analogue, methoxycoronaridine (MC), on alcohol intake.
Selectively bred alcohol-preferring rats received a single intraperitoneal injection of vehicle or 5, 20 and 40 mg/kg of MC at AM, and their consumption of alcohol, water and food Cited by: When considering oral consumption of ethanol in humans and animals, sensory modalities such as taste, olfaction, and chemosensory irritation are three independent systems that each play an important role in the acceptance or rejection of the alcohol solution Cited by: After a two-week period of habituation to ethanol in two-bottle choice, alcohol-preferring (P) and Wistar rats received ethanol ( g/kg) every 6 hours for consecutive days via gavage.
We undertook Experiment 2 to determine whether exposure to ethanol-consuming dams has long-lasting effects on voluntary ethanol consumption by pups. We exposed pups to an ethanol-consuming dam for 8 days prior to weaning, and 1, 2, 4, or 6 weeks later compared the ethanol consumption of independent groups of subjects with that of subjects of Cited by: 4.
These experiments examined the hypothesis that isolation-rearing and strain influence hedonic mechanisms. In experiment 1, voluntary consumption of ethanol and water was monitored in the home cage of Fawn Hooded (FH) and Wistar rats.
FH rats were found to consume more ethanol at low concentrations than Wistar rats, independent of rearing Cited by: Results indicate that the drug increases ethanol consumption following the injection but decreases consumption of ethanol on subsequent postdrug days.
There was an attenuation in these effects from the firts to the third injection. Although a dose effect was not determined, changes in ethanol consumption were greater with the higher by: Ethanol is a widely used drug whose mechanism of action, despite intensive study, remains uncertain.
Biochemical and electrophysiological experiments have identified receptors and ion channels whose functions are altered at physiological concentrations of ethanol.
DBH knockout mice demonstrate a reduced voluntary ethanol consumption (Weinshenker et al, ), and while this reduction may result from a deficit in ethanol reward, it also may be due to the Cited by: Abstract.
A human experimental model of the ethanol self-administration aspect of alcoholism is described which is sensitive to pharmacological manipulations which influence alcoholics 1 disposition to drink.
Volunteer male alcoholics are permitted to self-administer ethanol daily under experimental conditions which prevent the wide spontaneous fluctuation of intake Cited by: LHb lesion increased the rate at which rats escalated voluntary ethanol consumption in a two bottle choice paradigm, resulted in higher levels of maintained intake relative to sham rats both before and after a period of abstinence, and gave rise to higher BECs relative to sham by: Spontaneous turning behavior and locomotor activity were evaluated for their ability to predict differences in the voluntary consumption of ethanol in male Long–Evans rats.
Animals were assessed for their preferred direction of turning behavior and for high vs. low levels of spontaneous locomotor activity, as determined during nocturnal testing in a by: Environmental enrichment (EE) provides a non-pharmacological tool to alter drug-induced reward, yet its effects on ethanol-induced reward remain controversial.
We analyzed adolescent vs. adult Cited by: 7. We found that the intensity (amount) and duration of ethanol exposure, indexed by BEC, is critical to produce increased drinking in mice.
Specifically, blood ethanol concentrations must regularly exceed mg/dl for the escalation in drinking to by: The sucrose animals had 4–5 days of exposure to the sucrose solution, whereas the animals in ethanol groups had 0–1 days of exposure to the ethanol plus sucrose solution.
However, previous work in our laboratory has shown that exposure to ethanol solutions for 7 days or 7 weeks does not produce habituation of the dopamine response observed during ethanol consumption Cited by:.
Schedule-induced vs. home cage ethanol consumption: Influence of food deprivation Article (PDF Available) in Bulletin of the Psychonomic Society 19(1) October with 13 Reads.Approximately million people report alcohol use and tobacco dependence in the United States (US) during a single year.
The economic costs associated with tobacco and alcohol use total nearly billion dollars per year in the US. It is increasingly clear that both substances influence consumption of the other, likely due to common genetic and molecular sites of by: On half of the animals from each preexposure condition were injected with 20 mg/kg cocaine, g/kg alcohol or the cocaine/alcohol combination before being restricted for 30 min to .